before we actually get into some of the findings and some of the associated health benefits. let's talk about caffeine and antioxidants briefly here so coffee contains caffeine as a lot of us know and the following antioxidants chlorogenic acid and caffeic acid. So we're going to briefly talk about these in more detail these oftentimes mediate health effects so caffeine and antioxidants. So I'm going to briefly talk about the mechanism of caffeine but the antioxidants often have very complex mechanisms.
We won't talk about it in this blog, so caffeine can actually cross the blood-brain barrier enter the brain, and have effects on neurons in our brain. so here is a neuron here so caffeine binds to adenosine receptors so it actually binds to several adenosine receptors a1 a2a a2b and a3 a2a it's binding to a2a is actually what mediates its stimulant effects and this leads to the release of excitatory neurotransmitters and this is going to become important when we talk about certain health effects later on.
So again caffeine can cross the blood-brain barrier enter the brain and bind to adenosine receptors and particularly h2a is what we see with its stimulatory effects and it oftentimes leads to increased excitatory neurotransmitters. so we're going to first talk about neurological health benefits that have been found to be associated with coffee. So, coffee consumption may reduce the risk of some neurological diseases including Parkinson's disease as was found in this article entitled meta-analysis of coffee drinking cigarette smoking. And the risk of Parkinson's disease and there may be a small reduction in risk of Alzheimer's disease with coffee consumption as well one mouse model actually demonstrated reduced beta-amyloid.
so, beta-amyloid is important in the pathogenesis or pathophysiology of Alzheimer's disease and these two articles both show some reduction in risk of Alzheimer's disease with coffee consumption or an associated reduction in risk so the two articles here are entitled caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta amyloid production so this was mentioned here and then the other article is alzheimer's disease and coffee a quantitative review so these are the two articles.
so, again this is a mouse model so we can't really say too much about this but there has been some evidence to show an association between coffee consumption and a reduced risk of Alzheimer's disease so also interesting now the next health benefits we're going to talk about with
regards to coffee consumption are in relation to mortality so in this review entitled coffee consumption and health umbrella review of meta-analyses of multiple
having coffee or consuming three cups of coffee per day after their heart attack it seemed to also have some associated benefits as well so again very interesting very important high coffee consumption seems to reduce or is associated with a reduced risk of all-cause mortality and is also associated with a decreased incidence
of an all-cause mortality from cardiovascular disease coronary heart disease and
cerebrovascular disease so things like
strokes now we're going to talk about
cancer as well
now again from the same review article
coffee consumption and health
umbrella review of meta-analyses of
multiple health outcomes
this article talked about a certain
meta-analysis of 40 cohort studies
and with regards to cohort studies
it's an observational study so they look
at groups of individuals who
have had high consumption of coffee and
groups that have not
and they compare them and what they
found was that in
from 40 cohort studies there was a
demonstrated associated reduction in
incidence of cancer
and this was again with high consumption
of coffee compared to the low
consumption of coffee or no coffee at
all
and the cancers that showed reduced
incidence
included liver cancer leukemia
endometrial cancer prostate cancer skin
cancers including melanoma
and an interesting point that was noted
was that when looking at studies
with associated risks of lung cancer in
coffee consumption
high cough consumption may actually
increase the risk of lung cancer
in smokers so very important to make
note of
in smokers high coffee consumption may
be associated with an increased risk of
lung cancer
but only in smokers in non-smokers this
does not seem to be the case
now we're going to talk about the liver
so we talked about the cohort studies
that have demonstrated reduced risk of
liver cancer but there's also some other
benefits
of coffee consumption in liver health as
well and it's all coming again from that
review article we talked about
so coffee consumption has been
demonstrated to help treat reduce
non-alcoholic fatty liver disease reduce
the risk
of liver fibrosis and reduce risk of
cirrhosis now we talked about this more
in detail in my non-alcoholic fatty
liver disease and diet
lessons so if you want more information
please check out that lesson
so again very important coughing
consumption helps reduce
the risk of these so non-alcohol fatty
liver disease
fibrosis of the liver so scarring of the
liver and it also reduces the risk of
cirrhosis
and what's important here is that any
consumption of coffee seems to lead to a
reduction so it doesn't matter if it's
very high
versus very low consumption of coffee
any consumption seems to
help reduce the risk of these diseases
but oftentimes three cups of coffee per
day seems to be the best dosing
now we're going to talk about metabolic
diseases as well so again coming from
the same review article
associations between coffee consumption
and reduced risk of type 2 diabetes have
been consistently found
so very important associations again
not causation but there's associations
between coughing consumption and reduced
risk of type 2 diabetes
and they've been consistently found now
there does seem to be some linear
relationship
at least up to six cups per day so as an
individual
increases their coughing assumption
their risk of type 2 diabetes seems to
decrease and usually it's a linear dose
dependent response up to
6 cups per day and again the association
appears independent of caffeine content
so
very important again so there's
something in coffee
independent of caffeine so we talked
about some of those antioxidants
that they may be mediating a lot of
these health benefits
so again decaffeinated coffee shows
similar findings
and then with regards to other metabolic
diseases high versus low coffee
consumption so you can think of
high coughing consumption as being three
or more cups per day low coffee
consumption maybe one
cup or less than one cup per day was
associated with
eight nine percent lower risk of
metabolic syndrome and lower risk of
gout as well
so very interesting now that we've
talked about some of the health benefits
of coffee consumption let's talk about
some of the health risks
so from this article entitled
ditreponoid steroid in tri-terpenoid
agonists of
liver ex receptors from diversified
terrestrial plants and marine sources
we see there are these compounds known
as
diterpenoids especially in unfiltered
coffee so unfiltered coffee contains dye
terpenoids including kathystoll and
call wheel sorry for the pronunciation
and diet terpenoids have been
demonstrated to increase ldl levels
so ldl you can think of the l as
lethal so this is the bad cholesterol
and it decreases
hdl levels the good cholesterol h for
healthy so
it increases bad cholesterol decreases
good cholesterol
so that is not a good thing and
components of coffee can cause temporary
increases in blood pressure as well so
this is another
health risk but again this is only
temporary increases in blood pressure
and it seems to only occur in casual
coffee drinkers so an individual who
drinks coffee consistently every day
does not seem to have the same effect
it's only with individuals who don't
drink coffee often
and have a coffee and then they have
this temporary increase in blood
pressure
now there are some associated health
risks with coughing consumption during
pregnancy as well
and again these findings come from this
review article
so high cough consumption during
pregnancy is associated with the
following harmful outcomes
so one of the associated harmful
outcomes with coffee consumption during
pregnancy include low birth weight so
babies born to mums who consume high
levels of coffee during pregnancy
oftentimes have a lower birth weight
there's also increased preterm birth so
increased risk of preterm labor
especially in the first and second
trimesters doesn't seem to occur in the
third trimester as much
so this is also very problematic and
there also seems to be an associated
increased risk of leukemia in childhood
in children who were born
to mothers that had high coffee
consumption during pregnancy
so again very very important to
recognize
the importance of not drinking coffee
during pregnancy so
we talk about high coughing consumption
but perhaps no coughing consumption at
all would be best during pregnancy
and there's some other health risks as
well these
come from the article caffeine and
headaches so caffeine is a known trigger
of migraines
and can be a cause of rebound headaches
especially after
ceasing consumption of caffeine or
coffee after a long period of time so
coffee or caffeine in the coffee acts as
an analgesic and
if an individual drinks a lot of coffee
for a long time and they stop they can
actually have a headache and this is
actually known as a rebound headache so
it's like they've been taking
a mild analgesic and then all of a
sudden they stop so they get these
rebound headaches
from that and again caffeine is also
known to trigger
migraines as well so migraines and
rebound headaches can be
something that occurs from coffee
consumption
and these other two articles one
entitled angiogenic effects of
caffeine in patients with anxiety
disorders and the other
entitled caffeine intake toxicity
independence and lifetime risk for
psychiatric and substance use disorders
in epidemiologic
and co twin control analysis both show
some
other health risks as well we talked
about caffeine increasing
neuroexcitatory
transmitters this can lead to emotional
disturbances
particularly stress and anxiety so if an
individual has
some underlying anxiety or some
underlying anxiety disorder
the caffeine can make it worse or can
trigger stress and anxiety
and again it's worse in patients with anxiety disorders and it seems to be the case where this
is particularly problematic when there's been greater than five cups of coffee consumed per day
and another issue with high consumption
of caffeine is insomnia so difficulty
falling asleep or difficulty sleeping
through the night and from those articles we also see that
caffeine can trigger panic attacks so
similarly to the anxiety component it
can trigger panic attacks
and this can also be another health risk
of caffeine
and there's this question does high
caffeine consumption increase risk of
psychiatric disorder so
is it that the patient has these
psychiatric disorders already and the
caffeine from the coffee
makes them worse or triggers them or is
it that the high caffeine consumption
increases the onset or prevalence of
psychiatric disorders particularly anxiety disorder

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